EXHIBIT 10.2
AGREEMENT
THIS
AGREEMENT (the
"AGREEMENT") made this
28th day of March,
2005 (the
"EFFECTIVE DATE") between OccuLogix(R), Inc. ("OCCULOGIX"), a corporation
incorporated under the laws of the State of Delaware, and Rheogenx(TM)
Biosciences Corporation (the "PURCHASER"),
a corporation
incorporated under the
laws of the State of Delaware.
WHEREAS
OccuLogix wishes to sell the Products (as hereinafter defined) to
the Purchaser, and the Purchaser wishes to
purchase the Products from OccuLogix,
under the terms provided herein.
AND
WHEREAS OccuLogix
and the Purchaser also desire to develop a joint
marketing relationship to promote the use
of the RHEO System and the Purchaser's
mobile apheresis business and to provide for certain other business
arrangements.
NOW
THEREFORE, in
consideration
of the mutual
covenants and
agreements
herein contained and other good and valuable consideration (the receipt and
sufficiency of which are hereby
acknowledged), the parties agree as follows:
ARTICLE 1
INTERPRETATION
1.1
DEFINITIONS.
In this Agreement, the following terms shall have
the
meanings set forth below, unless the
context requires otherwise:
"ADVERSE
PATIENT EVENT" means an "Unanticipated Adverse Device Effect"
that is reported or is reportable to the FDA under the Code of Federal
Regulations, Part 21 CFR 812, or any
successor regulation, and any "Adverse
Event" that is reported or is reportable under the Medical Device Reporting
regulations as defined in the Code of
Federal Regulations,
Part 21 CFR 803,
or
any successor regulation, in each case, whether or not such event is
actually
reported to the FDA.
"AFFILIATE(S)" means, in respect of a Person (the "FIRST PERSON"),
another
Person that, directly or indirectly: (i) controls the First
Person, (ii) is
controlled by the First Person or (iii) is
controlled
by the same Person
that
controls the First Person. In this
definition, "control" means ownership of more
than 50% of another Person or the power to
direct decisions of
another Person,
including the power to direct management and policies of another
Person whether
by reason of ownership, contract or
otherwise.
"BUSINESS
DAY" means a day,
other than a Saturday,
Sunday or statutory
holiday, when banks are generally open in the State of Florida for the
transaction of banking business.
"CHANGE OF
CONTROL" means the
occurrence of any of the following events:
(i) any Person acquires or becomes the
beneficial owner of,
or a combination of
Persons acquires or becomes the
beneficial
owner of, directly or indirectly,
more than 50% of the voting securities of the Purchaser, whether through the
acquisition of previously issued and
outstanding voting securities, or of voting
<PAGE>
securities that have not been previously
issued, or any combination thereof, or
any other transaction having a similar
effect; (ii) any
resolution is passed or
any action or proceeding is taken with
respect to the
liquidation,
dissolution
or winding-up of the Purchaser; (iii) the Purchaser merges with one or more
corporations other than a wholly-owned subsidiary, where a majority of the
Purchaser's stockholders immediately prior to such transaction do not hold a
majority of the issued and outstanding
securities of the
combined company,
but
in any case this Change of Control provision shall not be applied to the
solicited merger of the Purchaser with
HemaCare Corporation
regardless of the
outcome of the ownership of the
Purchaser's
securities
post-merger;
(iv) the
Purchaser sells, leases or otherwise
disposes of all or substantially all of its
assets and undertaking, whether pursuant to
one or more transactions; or (v) the
Purchaser enters into any transaction or
arrangement which
would have the same
or similar effect as the transactions
described in (ii), (iv) or (v).
"CONFIDENTIAL
INFORMATION" of a
party means
any and all
material and
information of a party or any of its Affiliates or licensors (in this
definition, the "DISCLOSING PARTY") which
has or may come into the possession or
knowledge of the other party or any of its
Affiliates (in this
definition, the
"RECIPIENT PARTY") in connection with or as a result of
entering into this
Agreement, including information concerning the Disclosing Party's past,
present, and future customers, suppliers, finances, affairs, technology and
business. For the purposes of this
definition,
"information"
and "material"
includes know-how, data, patents, copyrights, trade secrets, processes,
techniques, programs, designs, designs obtained by reproducing or reverse-
engineering product, formulae, marketing,
advertising,
financial,
commercial,
sales or programming materials, written materials, compositions, drawings,
proposals, notes, records, diagrams, computer programs, studies, work in
progress, visual demonstrations, ideas, concepts, and other data, in oral,
written, graphic, electronic or any other form or
medium whatsoever, and
shall
include all Intellectual Property Rights and any
information identified
by the
Disclosing Party as confidential, or which
the Recipient Party should reasonably
know would constitute Confidential
Information.
Notwithstanding the
foregoing,
"Confidential Information" does not include
the following information:
(i)
information
which is publicly
available when it is received by or
becomes known to the Recipient Party or which subsequently becomes
publicly available through no fault of the Recipient Party (but
such
information will be considered Confidential Information until such
time as it becomes publicly available);
(ii)
information
which is already
known to the
Recipient Party at the
time of its disclosure
to the Recipient Party by the Disclosing
Party and is not the subject of an obligation of confidence of any
kind;
(iii)
information which is independently developed by the Recipient
Party
without any use of or reference to the Confidential Information of
the Disclosing
Party where such independent development can be
established by
evidence that would be acceptable to a court of
competent jurisdiction; and
(iv)
information
which is received by
the Recipient Party in
good faith
from a third party whom the Recipient Party had no reason to
believe
was not lawfully
in possession of such information free of any
obligation of
confidence of any kind, but only until the Recipient
Party subsequently
comes to have reason to believe that such
information was
subject to an
obligation of confidence of any kind
when originally received.
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"FDA"
means the United States Food and Drug Administration.
"FDA
APPROVAL" means the approval of the FDA being sought by OccuLogix
for
the RHEO System for use in treatment of non-exudative age-related macular
degeneration (the specific labeling of
which treatment will be determined by the
FDA).
"FILTERS"
means the filters
described in Schedule 1 attached hereto, and
any new versions of such filters or
improvements
thereto, or replacement or
substitution filters, that OccuLogix,
in its sole
discretion, may from
time to
time sell in the regular course of its
business.
"GEOGRAPHIC AREA"
means any Canadian or U.S. city, town or municipality,
and its surrounding area to an extent of a 50-mile
radius thereabout,
that is
specified in the Geographic Areas Schedule,
attached hereto as Schedule 2, as it
may be amended from time to time by the
parties hereto.
"INTELLECTUAL PROPERTY RIGHTS" means:
(a)
any and all
proprietary
rights provided under
(i) patent law, (ii)
copyright law, (iii) trademark law, (iv) design patent or
industrial
design law,
(v) semi-conductor chip or mask work law or (vi)
any
other statutory provision or common law principle applicable to
this
Agreement, including
trade secret law, which may provide a right in
either ideas,
formulae,
algorithms,
concepts,
inventions,
documentation,
Confidential
Information or know-how generally, or
the expression or use of such ideas, formulae, algorithms,
concepts,
inventions or know-how; and
(b)
any and all
applications,
registrations,
licenses, sub-licenses,
franchises, agreements, renewals or any other evidence of a right
in
any of the foregoing.
"PATIENT
INFORMATION"
means all information, data and test results
collected by the Purchaser in connection with the use of the Products with
patients, provided that such information,
data and test results will be provided
to OccuLogix in such form so that the patients will not be identified in
accordance with the standard of de-identification
of protected health
information set forth in CFR ss.
164.514.
"PERSON"
means an individual, corporation, partnership, limited liability
company, trust, business trust,
association, joint stock company, joint venture,
pool, syndicate, sole proprietorship,
unincorporated
organization, governmental
authority or any other form of entity.
"PRODUCTS"
means, together, the
Pump, Tubing Sets and the Filters and any
new versions of such products or improvements thereto, or replacement or
substituted products, that OccuLogix,
in its sole
discretion, may from
time to
time sell in the regular course of its
business.
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<PAGE>
"PUMP"
means the OctoNova(R)
Apheresis Machine described in Schedule 1
attached hereto and any new versions of
such product or improvement thereto, or
replacement or substitution products, that OccuLogix, in its sole discretion,
may from time to time sell in the regular
course of its business.
"RHEO
SYSTEM" means the Products used to perform Rheopheresis and
consisting of a Pump and a disposable
treatment set,
containing the Filters and
Tubing Sets, through which the patient's
blood circulates.
"RHEO
THERAPY" means the performance of Rheopheresis using the RHEO
System.
"SECTION
510 APPROVAL" means approval of the FDA granted pursuant to
section 510(k) of the U.S. Food, Drug and
Cosmetic Act.
"THIRD
PARTY" shall mean any
Person other than
OccuLogix, the
Purchaser
and their respective Affiliates.
"TUBING
SETS" means the
disposable
tubing sets forming
part of the RHEO
System.
1.2
EXTENDED MEANINGS. Unless the context requires otherwise, words
importing the singular include the plural and vice versa,
and words importing
gender include all genders. The terms "including" and "include" shall mean
"including without limitation" and "include
without limitation," respectively.
1.3
REFERENCES TO "OCCULOGIX" AND "PURCHASER". Unless the context
requires
otherwise, in this Agreement, references to "OCCULOGIX" are references to
OccuLogix, Inc. and all of its Affiliates,
and references to the "PURCHASER" are
references to Rheogenx Biosciences
Corporation and PhereSys Therapeutics and all
of their respective Affiliates.
1.4
CURRENCY. Unless
otherwise stated, all
dollar amounts referred to in
this Agreement are in United States
dollars.
1.5 LEGAL
COUNSEL. The parties
acknowledge
that their
respective legal
counsel have reviewed and participated in settling the terms of this
Agreement
and that any rule of construction to the effect that any ambiguity is to be
resolved against the drafting party shall not be applicable in the
interpretation of this Agreement.
1.6
REMEDIES CUMULATIVE.
Unless otherwise
expressly stated
herein, all
rights and remedies of either party under
this Agreement are in addition to such
party's other rights and remedies and are
cumulative, not alternative.
1.7
AGREEMENT AND SCHEDULE
AMENDMENT AND SUPPLEMENT. Except as expressly
set out in this Agreement, this Agreement, including each Schedule to this
Agreement, may not be amended or
supplemented except by mutual written agreement
of at least one authorized representative of each of the parties. Any such
agreement will expressly state that it is intended to amend
or supplement, as
the case may be, this Agreement.
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<PAGE>
1.8
SCHEDULES. This
Agreement includes and incorporates the following
schedules:
Schedule 1 - Product List and Prices
Schedule 2 - Geographic Areas Schedule
ARTICLE 2
PRODUCTS AND PATIENT INFORMATION
2.1
PURCHASE. Upon submission of a purchase order by the Purchaser
("ORDER") and acknowledgment and acceptance of such Order by OccuLogix,
OccuLogix will sell, and the Purchaser will
purchase, the Products at the prices
specified in Schedule 1 attached
hereto, as such prices may be adjusted
from
time to time pursuant to Section 2.7
hereof. Each such Order shall be in writing
in a form reasonably acceptable to OccuLogix and shall
specify the quantity of
each of the Products ordered, the place of delivery and the
requested delivery
date therefor, which shall not be less than 60 days after the date of such
Order. Until such time as the FDA
Approval is granted,
OccuLogix will have
no
obligation to deliver any Products to the Purchaser at any location in the
United States. In the event of a conflict
between the terms and
conditions of
any Order and this Agreement, the terms and conditions of this
Agreement shall
prevail, and any additional or different
terms shall be of no force or effect.
2.2 RIGHT
TO REJECT ORDERS.
OccuLogix shall have
the right to reject any
order placed by the Purchaser if the Purchaser is in breach of any of its
material obligations under this Agreement.
The Purchaser's Order shall be deemed
accepted when it is acknowledged and
accepted by OccuLogix in writing. Any Order
that OccuLogix fails to accept or reject
within five business days of receipt of
such Order from Purchaser shall be deemed accepted. Subject to Section 2.3,
below, the Purchaser may not cancel any
order after it is accepted by OccuLogix
without the written consent of OccuLogix.
2.3 DELIVERY SCHEDULE. OccuLogix shall
make commercially reasonable efforts to deliver the
Products in accordance with
the delivery schedules set forth in the
accepted Orders.
However, if
anything
beyond the control of OccuLogix prevents OccuLogix from completely filling
Orders accepted by OccuLogix in accordance with this Section 2.3,
OccuLogix
shall immediately notify Purchaser of any
such delay in writing and the expected
delivery date(s) for the unshipped
portion of the Order.
The Purchaser
shall
have the right to cancel the unshipped
portion of any Order
for which OccuLogix
indicates an expected delivery date of more than 45 days after
the original
delivery date requested by the Purchaser,
provided that the
Purchaser notifies
OccuLogix, within five business days of
receipt of notice of delayed delivery,
of the Purchaser's intention to exercise of
its right of cancellation under this
Section 2.3.
2.4
DELIVERY. All Products
supplied under this Agreement shall be shipped
f.o.b. the place of manufacture to such
location as designated by the Purchaser.
Title and risk of loss and damage to the
Products purchased by the Purchaser
hereunder shall pass to the Purchaser upon
receipt by delivery to the applicable
carrier.
2.5
PACKAGING.
All Products supplied under this Agreement shall be
packaged in such manner as OccuLogix reasonably determines, in all cases
consistent with industry practice for the
shipment of similar goods.
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<PAGE>
2.6
INABILITY TO SUPPLY. OccuLogix shall not be liable for
failure to
supply Products or for the late delivery of
Products if (i) OccuLogix orders the
Products (or components thereof) from its supplier(s) and
such supplier(s) fail
to deliver such Products or components thereof) or (ii) OccuLogix's supplier
terminates its agreements with OccuLogix for the supply of the Products
(or
components thereof). In the event of the
occurrence of (i) above, OccuLogix will
(i) use commercially reasonable efforts to notify the Purchaser as
promptly as
practicable of the circumstances,
(ii) discuss with the
Purchaser ways in which
to remedy the circumstances and (iii) use commercially
reasonably
efforts to
supply the ordered Products as promptly as
practicable thereafter.
2.7 MOST
FAVOURED NATION. OccuLogix will not sell the Products to the
Purchaser at a price that is less
favourable than OccuLogix's lowest list price
in effect at the time of submission of the Order.
In the event that
OccuLogix
sells Products to another customer at a price per unit
(including any
rebates,
incentives, offsets or other discounts) that is less than the price per
unit
payable by the Purchaser pursuant to this
Agreement, OccuLogix shall provide the
Purchaser with a credit for any excess
amount charged to the Purchaser with
respect to any Products which were shipped to the
Purchaser after the date on
which such lower price was offered to such other customer. In addition,
OccuLogix will use its best efforts to expedite processing of all accepted
orders from the Purchaser and shall make
all commercially
reasonable efforts to
prioritize the processing, shipment and delivery of the
Purchaser's Orders. For
greater certainty, commercially reasonable
efforts will not require OccuLogix to
fill any Orders submitted by the Purchaser before filling any orders of
OccuLogix's other customers which were
submitted prior to the submission of the
Purchaser's Orders, but will require OccuLogix to fill
any Orders submitted by
Purchaser before filling any orders of
OccuLogix's other
customers which
were
submitted after the submission of the
Purchaser's Orders.
2.8
PATIENT INFORMATION.
The Purchaser will provide OccuLogix with copies
of such Patient Information as OccuLogix may reasonably request from time to
time. The parties agree that the Patient
Information shall be collected and held
in accordance with applicable privacy
legislation.
2.9
APPROVALS. OccuLogix
agrees to seek Section 510 Approval for the Pump
for non-Rheopheresis therapies, at its own
cost and expense.
2.10
NOTICE OF ADVERSE
EFFECTS. OccuLogix
shall provide notice to the
Purchaser promptly upon OccuLogix learning
of any Adverse Patient Event that is
experienced by patients during use of any
of the Products.
ARTICLE 3
MARKETING AND OTHER RELATIONSHIPS
3.1 JOINT
MARKETING CAMPAIGN.
OccuLogix and
Purchaser shall cooperate in
connection with, and, as described below,
devote such resources as are necessary
for, the preparation and implementation of
a joint marketing campaign to promote
both the RHEO System and the Purchaser's
mobile apheresis business, in all cases
subject to applicable law, including any necessary
approvals from the FDA
and
any labeling restrictions or follow-on requirements imposed thereby ("JOINT
MARKETING CAMPAIGN").
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<PAGE>
The Joint
Marketing Campaign shall include the following:
(a) Preparation of written materials and other media used in
the joint
marketing to,
and/or education of, healthcare institutions,
healthcare
facilities, healthcare
providers
(collectively,
"HEALTHCARE MARKET"), healthcare recipients and others;
(b)
The contribution of suitable resources, including personnel as
determined by the parties' representatives, as set forth below;
(c)
Cost sharing for
the preparation
and production of marketing and
educational materials;
(d)
Co-sponsorship
of seminars, meetings, presentations and other
promotional and educational events;
(e)
Co-promotion
to the Healthcare Market, including healthcare
providers' facilities
and practices, and at
healthcare
facilities
and institutions,
as may be agreed upon by OccuLogix and the
Purchaser;
(f)
Suitably
positioned
links on each
party's websites to the other
party's websites,
in each case with a brief description of the
relationship established by this Agreement, with such language to
be
approved in advance by both parties;
(g)
Coordination of
any and all necessary joint activities with respect
to third party payors, insurance, billers and/or intermediaries;
and
(h)
All other
activities and
materials as agreed upon by the parties in
writing.
In order to develop and implement the Joint Marketing Campaign,
representativesof OccuLogix and the Purchaser shall
meet within sixty (60) days
of the Effective Date to determine the resources
necessary to proceed
with the
development and implementation of the Joint
Marketing Campaign,
and to discuss
allocating such resources as they believe
desirable to ensure a successful Joint
Marketing Campaign. Representatives of OccuLogix and the Purchaser shall
thereafter meet regularly to analyze the
effectiveness
of the Joint
Marketing
Campaign and revise such Joint Marketing Campaign based on the then prevalent
market conditions and, among other
things, changes in the
Purchaser's
service
offering and markets served. Notwithstanding any other provision of this
Agreement, neither party shall use any promotional material or advertising
relating in any manner to the other party, or the other party's business,
without such other party's written consent other than such materi