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Deposit Agreement

Account Control Agreement

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This Account Control Agreement involves

Shire plc | HOLDERS OF AMERICAN DEPOSITARY RECEIPTS | JPMORGAN CHASE BANK, N.A.

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Title: Deposit Agreement
Governing Law: New York     Date: 11/25/2005
Industry: BIOTRX     Sector: HEALTH

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Exhibit 4

Exhibit 4.01


 

SHIRE plc

AND

JPMORGAN CHASE BANK, N.A.
As Depositary

AND

HOLDERS OF AMERICAN DEPOSITARY RECEIPTS


Deposit Agreement

Dated as of November 21, 2005

 






TABLE OF CONTENTS

 

 

 

 

Page 

PARTIES

 

 

 

1 

RECITALS

 

 

 

1 

Section 1.

 

Certain Definitions 

 

 

(a)

 

                   ADR Register 

 

1 

(b)

 

                   ADRs 

 

1 

(c)

 

                   ADS 

 

1 

(d)

 

                   Custodian 

 

1 

(e)

 

                   Delivery Order 

 

1 

(f)

 

                   Deposited Securities 

 

1 

(g)

 

                   Holder 

 

2 

(h)

 

                   Securities Act of 1933 

 

2 

(i)

 

                   Securities Exchange Act of 1934 

 

2 

(j)

 

                   Shares 

 

2 

(k)

 

                   Transfer Office 

 

2 

(l)

 

                   Withdrawal Order 

 

2 

Section 2.

 

ADR Certificates 

 

2 

Section 3.

 

Deposit of Shares 

 

2 

Section 4.

 

Issue of ADRs 

 

3 

Section 5.

 

Distributions on Deposited Securities 

 

3 

Section 6.

 

Withdrawal of Deposited Securities 

 

3 

Section 7.

 

Substitution of ADRs 

 

3 

Section 8.

 

Cancellation and Destruction of ADRs 

 

4 

Section 9.

 

The Custodian 

 

4 

Section 10.

 

Co-Registrars and Co-Transfer Agents 

 

4 

Section 11.

 

Lists of Holders

 

4 

Section 12.

 

Depositary's Agents 

 

4 

Section 13.

 

Successor Depositary 

 

4 

Section 14.

 

Reports 

 

5 

Section 15.

 

Additional Shares 

 

6 

Section 16.

 

Indemnification 

 

6 

Section 17.

 

Notices 

 

7 

Section 18.

 

Miscellaneous 

 

7 

TESTIMONIUM 

 

8 

 

 

 

 

 

SIGNATURES 

 

8 

 

- i -

 


 

 

 

 

 

 

Page 

EXHIBIT A

FORM OF FACE OF ADR 

 

A-1 

 

 

 

                   Introductory Paragraph 

 

A-1 

 

 

 

 

 

 

(1

) 

 

Issuance of ADRs 

 

A-2 

(2

) 

 

Withdrawal of Deposited Securities 

 

A-2 

(3

) 

 

Transfers of ADRs 

 

A-3 

(4

) 

 

Certain Limitations 

 

A-3 

(5

) 

 

Taxes 

 

A-3 

(6

) 

 

Disclosure of Interests 

 

A-4 

(7

) 

 

Charges of Depositary 

 

A-5 

(8

) 

 

Available Information 

 

A-5 

(9

) 

 

Execution 

 

A-5 

 

 

 

                Signature of Depositary 

 

A-5 

 

 

 

                Address of Depositary's Office 

 

A-5 

 

 

 

FORM OF REVERSE OF ADR

 

A-6 

 

 

 

 

 

 

(10

) 

 

Distributions on Deposited Securities 

 

A-6 

(11

) 

 

Record Dates 

 

A-7 

(12

) 

 

Voting of Deposited Securities 

 

A-7 

(13

) 

 

Changes Affecting Deposited Securities 

 

A-8 

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